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For patients

We offer resources to help eligible patients navigate insurance coverage and financial assistance options. When you enroll in Pfizer Hemophilia Connect, you can:

  • Speak to a Patient Case Manager (PCM) to address questions about insurance coverage
  • Understand eligibility for Pfizer’s support programs—including financial assistance resources such as co-pay savings for eligible patients
  • Receive educational resources about accessing your Pfizer hemophilia products

For healthcare providers

We can answer questions about coverage, reimbursement, and access to help ensure patients receive the support they need. We also provide resources to help patients navigate insurance access and support programs for their prescribed Pfizer hemophilia treatment.

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Patient case managers (PCMs)

Our PCMs provide live, one-on-one support for your Pfizer hemophilia treatment. Once enrolled in Pfizer Hemophilia Connect, a Pfizer PCM can provide information about insurance coverage and reimbursement, and financial assistance programs, if you are eligible. 

To enroll, please call 1-888-733-2030,
Monday through Friday,
8:00AM - 6:00PM ET.

To learn more about hemophilia, visit HereForHemophilia.com

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Have you been prescribed one of these treatments?
Click below to learn how Pfizer Hemophilia Connect can provide support for you.

HYMPAVZI®
(marstacimab-hncq)

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XYNTHA® antihemophilic factor (recombinant)

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BeneFIX® coagulation factor IX (recombinant)

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What is HYMPAVZI?

HYMPAVZI is a prescription medicine used regularly to prevent or reduce the frequency of bleeding episodes in adults and children 6 years of age and older with:

  • hemophilia A with or without factor VIII inhibitors, or 
  • hemophilia B with or without factor IX inhibitors. 

It is not known if HYMPAVZI is safe and effective in people receiving ongoing Immune Tolerance Induction (ITI).
It is not known if HYMPAVZI is safe and effective in children younger than 6 years of age. 

IMPORTANT SAFETY INFORMATION

Important: Before you start using HYMPAVZI, it is very important to talk to your healthcare provider about using factor VIII and factor IX products or “bypassing agents” (products that help blood clot but work in a different way than HYMPAVZI). Your healthcare provider may prescribe factor VIII or factor IX medicines or bypassing agents to treat episodes of breakthrough bleeding during your treatment with HYMPAVZI. Carefully follow your healthcare provider’s instructions regarding when to use these medicines and the prescribed dose during your treatment with HYMPAVZI. Do not use additional doses of HYMPAVZI to treat breakthrough bleeds.Before using HYMPAVZI, tell your healthcare provider about all of your medical conditions, including if you: 
  • have a planned surgery. Your healthcare provider may stop treatment with HYMPAVZI before your surgery. Talk to your healthcare provider about when to stop using HYMPAVZI and when to start it again if you have a planned surgery. 
  • have a severe short-term (acute) illness such as an infection or injury. 
  • have been told that you have a risk for blood clots. 
  • are pregnant or plan to become pregnant. HYMPAVZI may harm your unborn baby. 
Females who are able to become pregnant:
  • Your healthcare provider will do a pregnancy test before you start your treatment with HYMPAVZI. 
  • Use effective birth control (contraception) during treatment with HYMPAVZI and for at least 2 months after the last dose of HYMPAVZI. 
  • Tell your healthcare provider right away if you become pregnant or think that you may be pregnant during treatment with HYMPAVZI. 
  • are breastfeeding or plan to breastfeed. It is not known if HYMPAVZI passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.If you inject too much HYMPAVZI, call your healthcare provider or the Poison Help Line at 1-800-222-1222 or go to the nearest hospital emergency room right away.What are the possible side effects of HYMPAVZI?HYMPAVZI may cause serious side effects, including:
  • blood clots (thromboembolic events). HYMPAVZI may increase the risk for your blood to clot in blood vessels in your arm, leg, lung, or head, which can be life-threatening. Blood clots have happened in people using HYMPAVZI. You may have an increased risk of blood clots if you have certain risk factors. Stop using HYMPAVZI and get medical help right away if you develop any of these signs or symptoms of blood clots:
    • swelling or pain in your arms or legs 
    • redness or discoloration in your arms or legs 
    • shortness of breath 
    • pain in chest or upper back 
    • fast heart rate 
    • cough up blood 
    • feeling faint 
    • headache 
    • numbness in your face 
    • eye pain or swelling 
    • trouble seeing 
  • allergic reactions. HYMPAVZI may cause allergic reactions, including rash and itching. Stop using HYMPAVZI and get medical help right away if you develop any of the following symptoms of a severe allergic reaction:
    • swelling of your face, lips, mouth, or tongue 
    • trouble breathing 
    • wheezing 
    • dizziness or fainting 
    • fast heartbeat or pounding in your chest 
    • sweating 
The most common side effects of HYMPAVZI include: 
  • swelling, hardening, redness, bruising, bleeding, and pain at injection site 
  • headache 
  • fever
  • joint pain
  • diarrhea
  • itching 
  • rash  
These are not all the possible side effects of HYMPAVZI. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.Please see full Prescribing Information for HYMPAVZI.

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What is XYNTHA?

XYNTHA® Antihemophilic Factor (Recombinant) is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia A. Hemophilia A is also called classic hemophilia. Your doctor might also give you XYNTHA before surgical procedures.

XYNTHA is not used to treat von Willebrand’s disease.

Important Safety Information

  • Call your health care provider or go to the emergency department right away if you have any of the following symptoms because these may be signs of a serious allergic reaction: wheezing, difficulty breathing, chest tightness, turning blue (look at lips and gums), fast heartbeat, swelling of the face, faintness, rash, low blood pressure, or hives. XYNTHA contains trace amounts of hamster protein. You may develop an allergic reaction to these proteins. Tell your health care provider if you have had an allergic reaction to hamster protein.
  • Call your health care provider right away if bleeding is not controlled after using XYNTHA; this may be a sign of an inhibitor, an antibody that may stop XYNTHA from working properly. Your health care provider may need to take blood tests to monitor for inhibitors
  • Across all clinical studies, the most common side effects (10% or more) with XYNTHA in adult and pediatric previously treated patients were headache (24% of subjects), joint pain (23%), fever (23%), and cough (12%). Other side effects reported in 5% or more of patients were diarrhea, vomiting, and weakness.
  • XYNTHA is an injectable medicine administered by intravenous (IV) infusion. You may experience local irritation when infusing XYNTHA after reconstitution in XYNTHA® SOLOFUSE®.

Please see full Prescribing Information for XYNTHA.

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What is BeneFIX?

BeneFIX, Coagulation Factor IX (Recombinant), is an injectable medicine that is used to help control and prevent bleeding in people with hemophilia B. Your doctor might also give you BeneFIX before surgical procedures.

BeneFIX is NOT used to treat hemophilia A.

Important Safety Information

  • BeneFIX is contraindicated in patients who have manifested life-threatening, immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, including hamster protein.
  • Call your health care provider right away if your bleeding is not controlled after using BeneFIX.
  • Allergic reactions may occur with BeneFIX. Call your health care provider or get emergency treatment right away if you have any of the following symptoms: wheezing, difficulty breathing, chest tightness, your lips and gums turning blue, fast heartbeat, facial swelling, faintness, rash, or hives.
  • Your body can make antibodies, called “inhibitors,” which may stop BeneFIX from working properly.
  • If you have risk factors for developing blood clots, such as a venous catheter through which BeneFIX is given by continuous infusion, BeneFIX may increase the risk of abnormal blood clots. The safety and efficacy of BeneFIX administration by continuous infusion have not been established.
  • Some common side effects of BeneFIX are fever, cough, nausea, injection site reaction, injection site pain, headache, dizziness, and rash.

Please see full Prescribing Information for BeneFIX.

This site is intended only for U.S. residents.

The health information contained in this site is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

HYMPAVZI, XYNTHA, and BeneFIX are registered trademarks of Pfizer Inc.
© 2026 Pfizer Inc. All rights reserved.
June 2026 PP-HYM-USA-1219